Abnormal uterine bleeding during puberty: to the pathogenesis and diagnosis

The objective: to study the genetic aspects of pathogenesis abnormal uterine bleeding during puberty (AUB PP) and evaluate effectiveness diagnostic measures taking into account presence or absence mutations in MTHFR C677T gene.Materials methods. Sixty girls with a history AUB PP were included main group 30 healthy without consisted control group. is divided three subgroups: 1st subgroup (n=20) – PP, born from mothers physiological pregnancy; 2d 2 form whose pregnancy was complicated by preeclampsia; 3d miscarriage.All persons examined reproductive menstrual functions, assessment hormonal status, family hereditary anamnesis, ultrasound examination pelvic organs dynamics cycle. Depending on duration severity compensatory disorders, anemia gene homocysteine ​​concentration determined their blood, blood clotting morphological status endometrium performed.Results. had complications significantly more often (reccurent miscarriages 28.0 %, preeclampsia - 25.8 %) than (14.0 % 12.2 respectively), 55,0 cases mutation detected, which absent girls. majority miscarriage (70.0 (60.0 7 6 times likely have gene, respectively, who pregnancies (10.0 %). Mutation found 3.3 girls.Serum ​​levels 6.0±1.2 8.0±1.0 μmol/L, did not differ those mutation. clinical picture state hemostasis system also this But hyperfibrinolysis pronounced mutations.Conclusions. analysis demonstrates that patients preeclampsia, loss comparison physiologically normal pregnancy.